Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32679322 | 0.92 | TDP1 (0.46) | MAPK1TDP1TSHRATMMAPT | |
| SCHEMBL18112975 | 0.92 | TDP1 (0.46) | MAPK1TDP1TSHRATMMAPT | |
| SCHEMBL3254687 | 0.85 | MAPT (0.53) | MAPK1TDP1TSHRATMMAPT | |
| SCHEMBL2477068 | 0.84 | TSHR (0.52) | MAPK1TDP1TSHRATMALDH1A1 | |
| SCHEMBL29653309 | 0.84 | TSHR (0.52) | MAPK1TDP1TSHRATMALDH1A1 | |
| SCHEMBL3543539 | 0.82 | TSHR (0.50) | MAPK1TDP1TSHRATMMAPT | |
| SCHEMBL32679336 | 0.82 | TSHR (0.50) | MAPK1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL7784241 | 0.82 | TSHR (0.50) | MAPK1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL29740055 | 0.82 | ATM (0.55) | MAPK1TDP1ATMMAPTPKM | |
| SCHEMBL30110338 | 0.82 | TSHR (0.50) | MAPK1TDP1TSHRATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099672-A1 | FUSED IMIDAZOLE COMPOUNDS | ONO Pharmaceutical Co., Ltd. (JP) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015115673-A1 | FUSED IMIDAZOLE COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2015-08-06 | — | — | WO | disclosed |