Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.49 |
| ▸ | BRAF | P15056 | 7/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16974292 | 0.80 | AAK1 (0.49) | AAK1MAP4K4CDK8CLK2CDK7 | |
| SCHEMBL16974141 | 0.79 | AAK1 (0.56) | AAK1 | |
| SCHEMBL16974195 | 0.79 | HDAC1 (0.47) | FFAR4DYRK1AHDAC8 | |
| SCHEMBL28083853 | 0.74 | AAK1 (0.49) | AAK1BRAFFFAR4 | |
| SCHEMBL28275843 | 0.74 | AAK1 (0.52) | AAK1FFAR4 | |
| SCHEMBL28254805 | 0.73 | AAK1 (0.52) | AAK1MAP4K4CDK8CLK2CDK7 | |
| SCHEMBL16974295 | 0.73 | AAK1 (0.53) | AAK1BRAFMAP4K4CDK8CLK2 | |
| SCHEMBL28277287 | 0.69 | AAK1 (0.44) | AAK1BRAFFFAR4 | |
| SCHEMBL16974178 | 0.69 | AAK1 (0.43) | AAK1 | |
| SCHEMBL16974306 | 0.68 | AAK1 (0.72) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099673-A1 | QUINOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116492-A1 | QUINOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-08-06 | — | — | WO | disclosed |