Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.41 |
| ▸ | MME | P08473 | 10/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16932470 | 1.00 | FFAR4 (0.41) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL16939697 | 1.00 | FFAR4 (0.41) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL24428608 | 1.00 | FFAR4 (0.41) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL16939704 | 0.91 | FFAR4 (0.36) | FFAR4MMEACEFASN | |
| SCHEMBL19399201 | 0.87 | FFAR4 (0.36) | FFAR4MMEACEFASN | |
| SCHEMBL18595135 | 0.86 | FFAR4 (0.39) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL24380873 | 0.86 | FFAR4 (0.39) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL16939709 | 0.86 | FFAR4 (0.39) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL16974261 | 0.85 | FFAR4 (0.36) | FFAR4MMEACEFASNMMEL1 | |
| SCHEMBL24380920 | 0.85 | FFAR4 (0.36) | FFAR4MMEACEFASNMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099668-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116760-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |