Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 12/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 10/20 | 0.49 |
| ▸ | BRD4 | O60885 | 9/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.43 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16974436 | 0.89 | MAPK7 (0.53) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL16982791 | 0.83 | LRRK2 (0.70) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL619637 | 0.77 | LRRK2 (0.77) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL21143418 | 0.77 | BRD4 (0.47) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL616711 | 0.76 | LRRK2 (0.67) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL16982790 | 0.73 | LRRK2 (0.73) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL18313616 | 0.72 | MAPK7 (0.65) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL17839842 | 0.71 | MAPK7 (0.71) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL619514 | 0.70 | LRRK2 (0.74) | MAPK7LRRK2DCLK1BRD4NUAK1 | |
| SCHEMBL17721085 | 0.70 | LRRK2 (0.74) | MAPK7LRRK2DCLK1BRD4NUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099693-A1 | USES OF DIAZEPANE DERIVATIVES | Dana-Farber Cancer Institute, Inc. (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015117087-A1 | USES OF DIAZEPANE DERIVATIVES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-08-06 | — | — | WO | disclosed |