Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.76 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16930657 | 1.00 | MME (0.76) | MMEMMEL1 | |
| SCHEMBL16930440 | 0.93 | MME (0.77) | MMEMMEL1 | |
| SCHEMBL16930484 | 0.91 | MME (0.72) | MMEMMEL1 | |
| SCHEMBL16930576 | 0.90 | MME (0.82) | MMEMMEL1 | |
| SCHEMBL20306306 | 0.89 | MME (0.76) | MMEMMEL1 | |
| SCHEMBL16941055 | 0.88 | MME (0.75) | MMEMMEL1 | |
| SCHEMBL16939251 | 0.87 | MME (0.70) | MMEMMEL1 | |
| SCHEMBL16930532 | 0.86 | MME (1.00) | MMEMMEL1 | |
| SCHEMBL20280996 | 0.85 | MME (0.77) | MMEMMEL1 | |
| SCHEMBL16930601 | 0.85 | MME (0.77) | MMEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099678-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116786-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |