Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18868466 | 1.00 | MME (0.45) | MMECYP3A4CYP2C9ACE | |
| SCHEMBL16930630 | 1.00 | MME (0.45) | MMECYP3A4CYP2C9ACE | |
| SCHEMBL16975182 | 0.88 | MME (0.51) | MMEACE | |
| SCHEMBL16975153 | 0.88 | MME (0.51) | MMEACE | |
| SCHEMBL16930471 | 0.88 | MME (0.51) | MMEACE | |
| SCHEMBL18626433 | 0.86 | MME (0.51) | MMECYP3A4CYP2C9ACE | |
| SCHEMBL16941161 | 0.83 | MME (0.45) | MMECYP3A4CYP2C9 | |
| SCHEMBL28420704 | 0.75 | MME (0.39) | MMECYP3A4CYP2C9ACE | |
| SCHEMBL28466049 | 0.75 | MME (0.39) | MMECYP3A4CYP2C9 | |
| SCHEMBL28466050 | 0.75 | MME (0.39) | MMECYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099678-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116786-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |