Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 7/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975553 | 0.87 | ABL1 (0.38) | NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL18365223 | 0.85 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL16975218 | 0.84 | ABL1 (0.53) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL15260125 | 0.83 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL16975261 | 0.81 | ABL1 (0.40) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL15260270 | 0.80 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL15260010 | 0.78 | ABL1 (0.48) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL15260051 | 0.77 | ABL1 (0.43) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL15260100 | 0.77 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL15260180 | 0.76 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102203-A2 | ANTIBACTERIAL COMBINATIONS COMPRISING POLYMYXIN | SPERO GYRASE, INC. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015114452-A2 | ANTIBACTERIAL COMPOUNDS | BIOTA EUROPE LTD (GB) | 2015-08-06 | — | — | WO | disclosed |