Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640894 | 0.78 | CHEK2 (0.50) | ATRLRRK2 | |
| SCHEMBL2640812 | 0.74 | ATR (0.54) | ATR | |
| SCHEMBL16975604 | 0.74 | LRRK2 (0.45) | ATRLRRK2 | |
| SCHEMBL2640772 | 0.72 | ATR (0.51) | ATR | |
| SCHEMBL2640944 | 0.72 | ATR (0.49) | ATR | |
| SCHEMBL10277222 | 0.71 | ATR (0.48) | ATRLRRK2 | |
| SCHEMBL17034569 | 0.71 | ATR (0.48) | ATRLRRK2 | |
| SCHEMBL10310892 | 0.71 | ATR (0.46) | ATRLRRK2 | |
| SCHEMBL13195738 | 0.69 | ATR (0.63) | ATR | |
| SCHEMBL614761 | 0.69 | ATR (0.63) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096584-B2 | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-08-04 | — | — | US | disclosed |