Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.65 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | ROS1 | P08922 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16976359 | 0.87 | FABP6 (0.53) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL29783371 | 0.79 | FABP6 (1.00) | FABP6JAK2NTRK1JAK3ALK | |
| SCHEMBL29384774 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL2060404 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL3125131 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL886670 | 0.79 | FABP6 (1.00) | FABP6JAK2NTRK1JAK3ALK | |
| SCHEMBL31597716 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL2983127 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL22131596 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA | |
| SCHEMBL2062754 | 0.79 | FABP6 (0.67) | FABP6MAPKAPK2MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |