Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 20/20 | 0.75 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.66 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.66 |
| ▸ | TACR2 | P21452 | 1/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901932 | 0.87 | SSTR3 (0.80) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL23777544 | 0.81 | SSTR3 (0.81) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL13244746 | 0.81 | SSTR3 (0.81) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL9928528 | 0.81 | SSTR3 (0.81) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL13286216 | 0.80 | SSTR3 (0.71) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL6890516 | 0.80 | SSTR3 (0.81) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL6890067 | 0.80 | SSTR3 (0.81) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL9909895 | 0.80 | SSTR3 (0.68) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL12182088 | 0.77 | SSTR3 (0.71) | SSTR3KCNH2SSTR1SSTR5TACR2 | |
| SCHEMBL12686378 | 0.76 | SSTR3 (0.69) | SSTR3KCNH2SSTR1SSTR5TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648517-B1 | TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-05 | — | — | EP | disclosed |