Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.51 |
| ▸ | CDC7 | O00311 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.48 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14335980 | 0.92 | ALK (0.62) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14378024 | 0.92 | ALK (0.61) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14377770 | 0.91 | PIM1 (0.50) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14377793 | 0.87 | FLT1 (0.49) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14335342 | 0.87 | CDC7 (0.65) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14377091 | 0.87 | CDC7 (0.66) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14377086 | 0.86 | PDPK1 (0.53) | ALK | |
| SCHEMBL14377093 | 0.83 | ALK (0.66) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL15843199 | 0.83 | ALK (0.53) | ALKCDC7CCNE1CDK2DBF4 | |
| SCHEMBL14377081 | 0.83 | ALK (0.51) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723736-B1 | 7-Azaindole derivatives suitable for the treatment of cancers | MERCK PATENT GMBH (DE) | 2015-08-05 | — | — | EP | disclosed |