Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377086 | 0.84 | PDPK1 (0.53) | ALKPDPK1TNIK | |
| SCHEMBL15842457 | 0.83 | ALK (0.56) | ALKPDPK1 | |
| SCHEMBL14377786 | 0.82 | ALK (0.51) | ALKPDPK1 | |
| SCHEMBL14377085 | 0.81 | ALK (0.56) | ALKPDPK1TNIK | |
| SCHEMBL15257742 | 0.81 | PDPK1 (0.53) | ALKPDPK1TNIK | |
| SCHEMBL14378119 | 0.81 | ALK (0.46) | ALKPDPK1TNIK | |
| SCHEMBL15253790 | 0.81 | ALK (0.53) | ALKPDPK1TNIK | |
| SCHEMBL14377081 | 0.81 | ALK (0.51) | ALKPDPK1 | |
| SCHEMBL9888186 | 0.81 | ALK (0.63) | ALKPDPK1 | |
| SCHEMBL15253612 | 0.81 | ALK (0.57) | ALKPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723736-B1 | 7-Azaindole derivatives suitable for the treatment of cancers | MERCK PATENT GMBH (DE) | 2015-08-05 | — | — | EP | disclosed |