Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 14/20 | 0.56 |
| ▸ | GCK | P35557 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18676 | 0.88 | GCKR (0.51) | GCKRGCK | |
| SCHEMBL17386 | 0.88 | GCKR (0.51) | GCKRGCK | |
| SCHEMBL16985 | 0.86 | GCKR (0.72) | GCKRGCK | |
| SCHEMBL12088812 | 0.85 | GCKR (0.61) | GCKRGCKKDM4E | |
| SCHEMBL15818 | 0.84 | GCKR (0.66) | GCKRGCK | |
| SCHEMBL12078858 | 0.84 | GCKR (0.66) | GCKRGCK | |
| SCHEMBL17512 | 0.84 | GCKR (0.66) | GCKRGCK | |
| SCHEMBL12093521 | 0.84 | GCKR (0.74) | GCKRGCK | |
| SCHEMBL17714 | 0.84 | GCKR (0.74) | GCKRGCK | |
| SCHEMBL17845 | 0.81 | GCKR (0.57) | GCKRGCKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | claimed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | claimed |
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |