Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.61 |
| ▸ | EGFR | P00533 | 13/20 | 0.61 |
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697899 | 0.92 | BRAF (0.70) | BRAFEGFRKITCSF1R | |
| SCHEMBL13878771 | 0.76 | BRAF (0.78) | BRAFEGFRKITCSF1R | |
| SCHEMBL13878770 | 0.75 | BRAF (0.79) | BRAFEGFRKITCSF1RABL1 | |
| SCHEMBL1697953 | 0.75 | BRAF (0.58) | BRAFEGFRKITCSF1R | |
| SCHEMBL13878763 | 0.75 | BRAF (0.74) | BRAFEGFRKITCSF1RABL1 | |
| SCHEMBL15121678 | 0.74 | BRAF (0.56) | BRAFEGFRKITCSF1RABL1 | |
| SCHEMBL31620739 | 0.74 | BRAF (0.86) | BRAFEGFRKITCSF1R | |
| SCHEMBL13708173 | 0.73 | BRAF (0.76) | BRAFEGFRKITCSF1RABL1 | |
| SCHEMBL1698180 | 0.73 | BRAF (0.55) | BRAFEGFRKITCSF1R | |
| SCHEMBL20912769 | 0.73 | KIT (0.71) | BRAFEGFRKITABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576566-A1 | THIENO (2, 3B) PYRAZINE COMPOUNDS AS B - RAF INHIBITORS | MSD Oss B.V. (NL) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011147764-A1 | THIENO (2, 3B) PYRAZINE COMPOUNDS AS B - RAF INHIBITORS | N.V. ORGANON (NL) | 2011-12-01 | — | — | WO | disclosed |