SCHEMBL1698332

SCHEMBL1698332

O=C(C[C@H]1CC[C@H](O)CC1)NC1CCCCC1

nearest known ligand 0.79

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 7/20 0.79
HPGD P15428 3/20 0.79
KMT2A Q03164 2/20 0.79
LMNA P02545 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.50
ALDH1A1 P00352 2/20 0.50
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
MEN1 O00255 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
EPHX2 P34913 3/20 0.47
CYP3A4 P08684 2/20 0.47
MAPT P10636 1/20 0.47
KDM4E B2RXH2 1/20 0.47
CYP2C19 P33261 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24574267 0.88 EPHX1 (1.00) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL3655854 0.88 EPHX1 (1.00) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL21442929 0.88 EPHX1 (1.00) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL24490081 0.88 EPHX1 (1.00) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL22055470 0.88 EPHX1 (1.00) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL22813414 0.86 EPHX1 (0.80) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL16437128 0.86 EPHX1 (0.96) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL27192692 0.84 EPHX1 (0.92) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL4098357 0.82 KMT2A (0.72) EPHX1HPGDKMT2ALMNASMN1; SMN2
SCHEMBL1698397 0.80 EPHX1 (0.76) EPHX1HPGDKMT2ALMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2183245-B1 DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS HOFFMANN LA ROCHE (CH) 2014-07-09 EP disclosed
EP-2582705-A1 ANELLATED PYRIDINE COMPOUNDS AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS F.HOFFMANN-LA ROCHE AG (CH) 2013-04-24 EP disclosed
WO-2011161009-A1 ANELLATED PYRIDINE COMPOUNDS AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2011-12-29 WO disclosed