Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 3/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24380853 | 1.00 | PAK1 (0.36) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL24380864 | 0.92 | PAK1 (0.34) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL24380867 | 0.92 | PAK1 (0.34) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL16942438 | 0.92 | PAK1 (0.36) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL24381008 | 0.92 | PAK1 (0.34) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL19086029 | 0.92 | PAK1 (0.34) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL24381007 | 0.91 | FFAR4 (0.34) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL24381004 | 0.91 | FFAR4 (0.34) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL19695660 | 0.90 | MME (0.36) | PAK1MMEACEFFAR4FASN | |
| SCHEMBL24380891 | 0.90 | PAK1 (0.33) | PAK1MMEACEFFAR4FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015116760-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |