Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 18/20 | 0.62 |
| ▸ | CSF1R | P07333 | 17/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.62 |
| ▸ | KIT | P10721 | 4/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978580 | 0.92 | CSF1R (0.52) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1699067 | 0.88 | FLT3 (0.80) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698583 | 0.88 | FLT3 (0.47) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698961 | 0.82 | FLT3 (0.59) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL9978918 | 0.81 | FLT3 (0.66) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL20484791 | 0.79 | FLT3 (0.94) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698796 | 0.79 | FLT3 (0.94) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL29766467 | 0.79 | FLT3 (0.94) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698589 | 0.79 | FLT3 (0.94) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL15388862 | 0.78 | FLT3 (0.64) | FLT3CSF1RPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011150198-A1 | AZOLYL UREA COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | claimed |
| WO-2011150198-A1 | AZOLYL UREA COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |