Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.54 |
| ▸ | FYN | P06241 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532196 | 0.88 | PIK3CA (0.55) | PIK3CAFYNKDM4EMAPK1ALDH1A1 | |
| SCHEMBL533182 | 0.83 | PIK3CA (0.71) | PIK3CAFYNKDM4EMAPK1ALDH1A1 | |
| SCHEMBL16986790 | 0.83 | PIK3CA (0.68) | PIK3CAFYNKDM4EALDH1A1CFTR | |
| SCHEMBL532217 | 0.80 | PIK3CA (0.64) | PIK3CAFYNKDM4EMAPK1ALDH1A1 | |
| SCHEMBL532633 | 0.75 | PIK3CA (0.74) | PIK3CAFYNKDM4EMAPK1ALDH1A1 | |
| SCHEMBL2121133 | 0.75 | PIK3CA (0.77) | PIK3CAFYNCFTRSMPD3 | |
| SCHEMBL15975820 | 0.73 | PIK3CA (0.59) | PIK3CAFYNCFTRSMPD3 | |
| SCHEMBL532197 | 0.73 | SMPD3 (0.49) | PIK3CAKDM4EMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL533110 | 0.73 | PIK3CA (0.70) | PIK3CAFYNCFTRSMPD3 | |
| SCHEMBL532289 | 0.72 | PIK3CA (0.67) | PIK3CAFYNKDM4EMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414369-B1 | IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES | FUNDACIÓN CT NAC DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2015-08-12 | — | — | EP | claimed |