Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 9/20 | 0.44 |
| ▸ | AKT2 | P31751 | 6/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986824 | 0.94 | BCHE (0.52) | CCR3BCHEAKT1AKT2CHRM4 | |
| SCHEMBL16986833 | 0.93 | BCHE (0.46) | CCR3BCHEAKT1AKT2CHRM2 | |
| SCHEMBL16986917 | 0.93 | BCHE (0.46) | CCR3BCHEAKT1AKT2CHRM4 | |
| SCHEMBL16986925 | 0.93 | BCHE (0.48) | CCR3BCHEAKT1AKT2CHRM4 | |
| SCHEMBL16986853 | 0.92 | BCHE (0.46) | CCR3BCHEAKT1AKT2CHRM4 | |
| SCHEMBL16986892 | 0.91 | CHRM2 (0.47) | CCR3BCHEAKT1AKT2CHRM4 | |
| SCHEMBL16986872 | 0.91 | AKT1 (0.45) | CCR3BCHEAKT1AKT2CHRM2 | |
| SCHEMBL235731 | 0.91 | AKT1 (0.54) | CCR3AKT1AKT2POLBKMT2A | |
| SCHEMBL16986855 | 0.90 | BCHE (0.48) | CCR3BCHEAKT1AKT2CHRM4 | |
| SCHEMBL16986826 | 0.90 | CHRM4 (0.44) | CCR3BCHEAKT1AKT2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | claimed |