Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.47 |
| ▸ | AKT2 | P31751 | 14/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986914 | 0.93 | AKT1 (0.48) | AKT1AKT2CHRM4 | |
| SCHEMBL16986808 | 0.92 | AKT1 (0.49) | AKT1AKT2CHRM4 | |
| SCHEMBL16986888 | 0.91 | AKT1 (0.52) | AKT1AKT2CHRM4 | |
| SCHEMBL16986830 | 0.90 | AKT1 (0.51) | AKT1AKT2CHRM4 | |
| SCHEMBL16986835 | 0.90 | AKT1 (0.47) | AKT1AKT2CHRM4 | |
| SCHEMBL235319 | 0.89 | AKT1 (0.52) | AKT1AKT2 | |
| SCHEMBL16986824 | 0.89 | BCHE (0.52) | AKT1AKT2CHRM4 | |
| SCHEMBL16986876 | 0.89 | AKT1 (0.48) | AKT1AKT2CHRM4 | |
| SCHEMBL16986864 | 0.88 | AKT1 (0.47) | AKT1AKT2CHRM4 | |
| SCHEMBL16986890 | 0.88 | AKT1 (0.45) | AKT1AKT2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | claimed |