SCHEMBL16986924

SCHEMBL16986924

COc1cc(CNC(=O)OC2CCN(Cc3ccc(-c4nc5c(cnc6cc(C)nn65)cc4-c4ccccc4)cc3)CC2)ccc1O

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 9/20 0.44
AKT2 P31751 9/20 0.44
MCHR1 Q99705 1/20 0.42
CHRM4 P08173 4/20 0.41
BCHE P06276 1/20 0.40
ACHE P22303 1/20 0.40
ADRB2 P07550 1/20 0.38
CHRM3 P20309 1/20 0.38
KCNH2 Q12809 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16986860 0.95 AKT1 (0.45) AKT1AKT2MCHR1CHRM4ACHE
SCHEMBL16986903 0.91 AKT1 (0.46) AKT1AKT2MCHR1CHRM4BCHE
SCHEMBL238253 0.91 AKT1 (0.48) AKT1AKT2MCHR1CHRM4BCHE
SCHEMBL16986908 0.89 AKT1 (0.47) AKT1AKT2CHRM4BCHE
SCHEMBL16986909 0.89 AKT1 (0.44) AKT1AKT2CHRM4BCHECHRM3
SCHEMBL16986830 0.88 AKT1 (0.51) AKT1AKT2CHRM4BCHECHRM3
SCHEMBL16986906 0.88 AKT1 (0.43) AKT1AKT2MCHR1CHRM4BCHE
SCHEMBL16986851 0.87 AKT1 (0.46) AKT1AKT2CHRM4BCHECHRM3
SCHEMBL16986852 0.87 AKT1 (0.43) AKT1AKT2CHRM4BCHECHRM3
SCHEMBL16986840 0.87 AKT1 (0.44) AKT1AKT2CHRM4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2406250-B1 INHIBITORS OF AKT ACTIVITY MERCK SHARP & DOHME (US) 2015-08-12 EP claimed