Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18418861 | 0.73 | NAMPT (0.40) | GSK3BDYRK1AMAPK14NAMPTCYP17A1 | |
| SCHEMBL2175532 | 0.72 | MAPK14 (0.47) | GSK3BDYRK1AMAPK14CYP17A1ATR | |
| SCHEMBL35210874 | 0.70 | SMN1; SMN2 (0.57) | GSK3BDYRK1AMAPK14BRD9CA1 | |
| SCHEMBL6845100 | 0.70 | MAPK14 (0.48) | GSK3BDYRK1AMAPK14ATRBRD9 | |
| SCHEMBL17844767 | 0.70 | KMT2A (0.49) | GSK3BDYRK1AMAPK14NAMPTCYP17A1 | |
| SCHEMBL19271750 | 0.69 | MAPK14 (0.47) | GSK3BDYRK1AMAPK14CYP17A1ATR | |
| SCHEMBL19300006 | 0.69 | MAPK14 (0.47) | GSK3BDYRK1AMAPK14CYP17A1ATR | |
| SCHEMBL352727 | 0.69 | GSK3B (0.42) | GSK3BDYRK1AMAPK14NAMPTCYP17A1 | |
| SCHEMBL955124 | 0.69 | GSK3B (0.37) | GSK3BDYRK1AMAPK14NAMPTCYP17A1 | |
| SCHEMBL955125 | 0.69 | CA1 (0.38) | GSK3BDYRK1AMAPK14NAMPTATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845973-B1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LTD (GB) | 2015-08-12 | — | — | EP | disclosed |