Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.72 |
| ▸ | JAK1 | P23458 | 9/20 | 0.72 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL16986950 | 0.87 | JAK1 (0.70) | JAK2JAK1EGLN2TYK2 | |
| Cyclopropane SCHEMBL16986951 | 0.86 | JAK2 (0.55) | JAK2JAK1EGLN2TYK2 | |
| SCHEMBL13944164 | 0.84 | JAK2 (0.92) | JAK2JAK1TYK2 | |
| SCHEMBL13944168 | 0.84 | JAK2 (0.92) | JAK2JAK1TYK2 | |
| SCHEMBL13031172 | 0.84 | JAK2 (1.00) | JAK2JAK1TYK2 | |
| SCHEMBL13943375 | 0.82 | JAK2 (0.67) | JAK2JAK1EGLN2 | |
| Cyclopropane SCHEMBL16986955 | 0.80 | JAK2 (0.61) | JAK2JAK1TYK2 | |
| Cyclopropane SCHEMBL16986947 | 0.80 | JAK1 (0.56) | JAK2JAK1TYK2 | |
| SCHEMBL2144827 | 0.79 | JAK2 (0.60) | JAK2JAK1EGLN2 | |
| Cyclohexane SCHEMBL16986948 | 0.79 | JAK1 (0.53) | JAK2JAK1EGLN2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057158-B1 | TRIAZOLE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LTD (GB) | 2015-08-12 | — | — | EP | claimed |