Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.73 |
| ▸ | JAK1 | P23458 | 12/20 | 0.53 |
| ▸ | JAK2 | O60674 | 10/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL16986950 | 0.85 | JAK1 (0.70) | MAP3K5JAK1JAK2TYK2EGLN2 | |
| SCHEMBL2772932 | 0.85 | MAP3K5 (1.00) | MAP3K5JAK1JAK2 | |
| SCHEMBL2789563 | 0.84 | JAK1 (0.69) | MAP3K5JAK1JAK2TYK2JAK3 | |
| SCHEMBL2787903 | 0.84 | JAK1 (0.73) | MAP3K5JAK1JAK2TYK2JAK3 | |
| SCHEMBL2788079 | 0.83 | MAP3K5 (0.85) | MAP3K5JAK1JAK2EGLN2 | |
| SCHEMBL2787002 | 0.82 | MAP3K5 (0.89) | MAP3K5JAK1JAK2TYK2 | |
| SCHEMBL2787966 | 0.82 | MAP3K5 (0.71) | MAP3K5JAK1JAK2JAK3 | |
| SCHEMBL2788369 | 0.81 | MAP3K5 (0.83) | MAP3K5JAK1JAK2TYK2EGLN2 | |
| SCHEMBL12317235 | 0.81 | MAP3K5 (0.72) | MAP3K5JAK1JAK2EGLN2 | |
| SCHEMBL2785356 | 0.80 | MAP3K5 (0.65) | MAP3K5JAK1JAK2TYK2EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057158-B1 | TRIAZOLE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LTD (GB) | 2015-08-12 | — | — | EP | claimed |