Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eleclazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.88 |
| ▸ | SCN1A | P35498 | 1/20 | 0.88 |
| ▸ | SCN4A | P35499 | 1/20 | 0.88 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.88 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.88 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.88 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.88 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.88 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.88 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eleclazine SCHEMBL16989317 | 0.95 | KCNH2 (0.88) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL29377130 | 0.94 | KCNH2 (1.00) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL14480722 | 0.94 | KCNH2 (1.00) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL16989336 | 0.93 | KCNH2 (0.98) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL16989316 | 0.93 | KCNH2 (0.84) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL16989318 | 0.91 | KCNH2 (0.91) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL16989341 | 0.90 | KCNH2 (0.80) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| Eleclazine SCHEMBL19923836 | 0.87 | KCNH2 (0.84) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL17014542 | 0.87 | SCN1A (0.86) | KCNH2SCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL14480581 | 0.86 | SCN1A (0.85) | KCNH2SCN1ASCN4ASCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273038-B2 | Solid forms of an ion channel modulator | GILEAD SCIENCES, INC. (US) | 2016-03-01 | — | — | US | claimed |
| US-20150225383-A1 | SOLID FORMS OF AN ION CHANNEL MODULATOR | GILEAD SCIENCES, INC. | 2015-08-13 | — | — | US | claimed |
| EP-3105227-A1 | SOLID FORMS OF AN ION CHANNEL MODULATOR | Gilead Sciences, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| US-9273038-B2 | Solid forms of an ion channel modulator | GILEAD SCIENCES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| WO-2015123434-A1 | SOLID FORMS OF AN ION CHANNEL MODULATOR | GILEAD SCIENCES, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
| US-20150225383-A1 | SOLID FORMS OF AN ION CHANNEL MODULATOR | GILEAD SCIENCES, INC. | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225383-A1 | SOLID FORMS OF AN ION CHANNEL MODULATOR | KCNN1, SCN4A, KCNN2 | KCNH2 13/4885SCN1A 19/4885SCN4A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.