Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 1.00 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.80 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16967105 | 1.00 | SCN9A (1.00) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL16967106 | 1.00 | SCN9A (1.00) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL16967109 | 1.00 | SCN9A (1.00) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL16967097 | 0.96 | SCN9A (1.00) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL16967095 | 0.96 | SCN9A (1.00) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL16967266 | 0.92 | SCN9A (1.00) | SCN9ASCN10A | |
| SCHEMBL16992664 | 0.92 | SCN9A (1.00) | SCN9ASCN10A | |
| SCHEMBL16967268 | 0.92 | SCN9A (1.00) | SCN9ASCN10A | |
| SCHEMBL16966980 | 0.92 | SCN9A (1.00) | SCN9ASCN10A | |
| SCHEMBL16966982 | 0.92 | SCN9A (1.00) | SCN9ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102569-A1 | 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF | AbbVie Inc. (US) | 2016-12-14 | — | — | EP | claimed |
| WO-2015119998-A1 | 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF | ABBVIE, INC. (US) | 2015-08-13 | — | — | WO | claimed |
| EP-3102569-A1 | 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF | AbbVie Inc. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015119998-A1 | 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF | ABBVIE, INC. (US) | 2015-08-13 | — | — | WO | disclosed |