Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 20/20 | 0.79 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.68 |
| ▸ | FLT4 | P35916 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | BLK | P51451 | 1/20 | 0.68 |
| ▸ | BMX | P51813 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.68 |
| ▸ | TAOK2 | Q9UL54 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993420 | 0.93 | FGFR1 (0.78) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993313 | 0.92 | FGFR1 (0.80) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993335 | 0.91 | FGFR1 (0.79) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993297 | 0.91 | FGFR1 (0.79) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993036 | 0.88 | FGFR1 (1.00) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL17910120 | 0.88 | FGFR1 (0.62) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993212 | 0.88 | FGFR1 (0.78) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993041 | 0.88 | FGFR1 (0.78) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993081 | 0.87 | FGFR1 (0.62) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993298 | 0.86 | FGFR1 (0.80) | FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102577-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS | Principia Biopharma Inc. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015120049-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS | PRINCIPIA BIOPHARMA, INC. (US) | 2015-08-13 | — | — | WO | disclosed |