Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 12/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | BLK | P51451 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169876 | 1.00 | TNK2 (0.44) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL122930 | 0.91 | TNK2 (0.46) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL122931 | 0.91 | TNK2 (0.46) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL166984 | 0.85 | TNK2 (0.43) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL166985 | 0.85 | TNK2 (0.43) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL167745 | 0.85 | TNK2 (0.43) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL167747 | 0.85 | TNK2 (0.43) | TNK2LCKKDRBLKFLT3 | |
| SCHEMBL122968 | 0.83 | TNK2 (0.52) | TNK2LCKKDRBTKTEK | |
| SCHEMBL122860 | 0.83 | TNK2 (0.52) | TNK2LCKKDRBTKTEK | |
| SCHEMBL169875 | 0.82 | TNK2 (0.52) | TNK2LCKKDRBTKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424368-A1 | PYRROLOTRIAZINE COMPOUNDS | Locus Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126960-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |