Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.48 |
| ▸ | AKT2 | P31751 | 13/20 | 0.48 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239510 | 1.00 | AKT1 (0.48) | AKT1AKT2SMOCHRM4WNT1 | |
| SCHEMBL234257 | 0.91 | AKT1 (0.50) | AKT1AKT2ACKR3 | |
| SCHEMBL237582 | 0.90 | AKT1 (0.51) | AKT1AKT2ACKR3 | |
| SCHEMBL16986825 | 0.90 | AKT1 (0.44) | AKT1AKT2CHRM4 | |
| SCHEMBL235764 | 0.89 | AKT1 (0.49) | AKT1AKT2ACKR3 | |
| SCHEMBL237143 | 0.89 | AKT1 (0.49) | AKT1AKT2ACKR3 | |
| SCHEMBL236766 | 0.88 | AKT1 (0.53) | AKT1AKT2CHRM4WNT1GSK3B | |
| SCHEMBL238162 | 0.88 | AKT1 (0.51) | AKT1AKT2CHRM4WNT1GSK3B | |
| SCHEMBL237858 | 0.88 | AKT1 (0.54) | AKT1AKT2CHRM4WNT1GSK3B | |
| SCHEMBL237127 | 0.87 | AKT1 (0.61) | AKT1AKT2CHRM4WNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |