Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CDK14 | O94921 | 8/20 | 0.49 |
| ▸ | CCNY | Q8ND76 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL959301 | 0.93 | POLB (0.56) | POLBCDK14CCNYSMN1; SMN2KDM4E | |
| SCHEMBL8261466 | 0.84 | CDK14 (0.54) | POLBCDK14CCNYSMN1; SMN2JAK1 | |
| SCHEMBL957511 | 0.83 | CDK14 (0.54) | CDK14CCNYHDAC1JAK1KMT2A | |
| SCHEMBL13993632 | 0.81 | CDK14 (0.56) | POLBCDK14CCNYJAK1 | |
| SCHEMBL13993635 | 0.81 | CDK14 (0.52) | POLBCDK14CCNYSMN1; SMN2JAK1 | |
| SCHEMBL954966 | 0.81 | CDK14 (0.55) | CDK14CCNYJAK1 | |
| SCHEMBL8261470 | 0.78 | CDK14 (0.53) | POLBCDK14CCNYSMN1; SMN2JAK1 | |
| SCHEMBL13993605 | 0.77 | CDK14 (0.47) | CDK14CCNY | |
| SCHEMBL22235816 | 0.77 | MAPT (0.53) | POLBSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL1286749 | 0.74 | CDK14 (0.53) | CDK14CCNYJAK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845973-B1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LTD (GB) | 2015-08-12 | — | — | EP | disclosed |