Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | UGCG | Q16739 | 2/20 | 0.41 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | OSBP | P22059 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16995493 | 0.94 | POLA1 (0.43) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL14534344 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL345099 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL17468531 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL863221 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL24141906 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL14046807 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL14538772 | 0.94 | POLA1 (0.50) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL14554227 | 0.92 | POLA1 (0.51) | POLA1CYP46A1PLA2G2AGBA1UGCG | |
| SCHEMBL22757123 | 0.89 | POLA1 (0.49) | POLA1CYP46A1PLA2G2AGBA1UGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2905336-A1 | Compositions and methods for inhibiting expression of a gene from the ebola | Alnylam Pharmaceuticals Inc. (US) | 2015-08-12 | — | — | EP | disclosed |