Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 19/20 | 0.77 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16601338 | 0.87 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16988972 | 0.87 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16988973 | 0.87 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16608243 | 0.87 | GRIN2B (0.72) | GRIN2B | |
| SCHEMBL16995956 | 0.83 | GRIN2B (0.67) | GRIN2B | |
| SCHEMBL16995619 | 0.80 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL30076156 | 0.80 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16601057 | 0.80 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16608255 | 0.79 | GRIN2B (0.78) | GRIN2B | |
| SCHEMBL18629614 | 0.79 | GRIN2B (0.78) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540324-B2 | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B | LUC THERAPEUTICS, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150225342-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225342-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | GRIN2B 4/4885CCR3 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.