Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27982866 | 1.00 | TSHR (0.60) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL28156489 | 1.00 | TSHR (0.60) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL27917020 | 1.00 | TSHR (0.60) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL23911270 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL28833305 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL28270001 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1HIF1AMAPT | |
| Pyridine SCHEMBL11825162 | 0.97 | — | — | |
| Piperazine SCHEMBL28224527 | 0.94 | TSHR (0.53) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL28144608 | 0.94 | TSHR (0.53) | TSHRNAPRTTDP1HIF1AMAPT | |
| Piperazine SCHEMBL28269434 | 0.94 | TSHR (0.53) | TSHRNAPRTTDP1HIF1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121424-A | Continuous reaction for preparing piperazine pyridine compound | 浙江瑞博制药有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-112915811-A | Composite filter membrane and preparation method thereof | 南京理工大学 | 2021-06-08 | — | — | CN | claimed |
| CN-110452200-A | Heterocyclic compound and organic light emitting apparatus comprising the heterocyclic compound | SAMSUNG DISPLAY CO LTD | 2019-11-15 | — | — | CN | claimed |
| CN-108822082-A | A kind of fluorine-containing pyridine piperazine acidamide compound and its application | 青岛科技大学 | 2018-11-16 | — | — | CN | claimed |
| CN-106519210-B | A kind of covalent organic polymer and its preparation method and application | 苏州大学 | 2018-11-02 | — | — | CN | claimed |
| CN-108203539-A | Automobile-use interior trim or exterior trim component and shipboard component | 铃木株式会社 | 2018-06-26 | — | — | CN | claimed |
| CN-103631093-B | The manufacture method of the organic light-emitting display device of photoresist and the use photoresist | 乐金显示有限公司 | 2018-03-20 | — | — | CN | claimed |
| CN-107735426-A | Low viscosity transparent polyamide | 汉高知识产权控股有限责任公司 | 2018-02-23 | — | — | CN | claimed |
| CN-105315298-B | A D A conjugated molecules and its preparation method and application based on seven and condensed ring unit | 中国科学院化学研究所 | 2017-10-10 | — | — | CN | claimed |
| CN-106543108-A | A kind of industrialized process for preparing of 3 propyIoxirane, 2 carbonyl ring propionic acid amide. | 成都丽凯手性技术有限公司 | 2017-03-29 | — | — | CN | claimed |
| CN-104059046-A | Flavonoid derivative and application thereof | JIANGSU NHWA PHARMACEUTICAL CO LTD | 2014-09-24 | — | — | CN | claimed |
| CN-104013626-A | Application of pyridine-piperazine compounds to prepare anti-HIV-1 medicines | UNIV SUN YAT SEN | 2014-09-03 | — | — | CN | claimed |
| CN-103992338-A | Copper complex based on dipyridine piperazine ligand and Anderson type polyacid, and synthetic method and application thereof | UNIV BOHAI | 2014-08-20 | — | — | CN | claimed |
| CN-102702076-B | Compound for preparing alvimopan and preparation process and application thereof | JIANGSU NHWA PHARMACEUTICAL CO LTD | 2014-06-04 | — | — | CN | claimed |
| CN-1660184-B | Combination of medicaiton containing extractive of herb of glabrous sarcandra, and preparation method and application | QI CHEN | 2010-12-08 | — | — | CN | claimed |
| CN-100577663-C | Fused heterocyclic kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2010-01-06 | — | — | CN | claimed |
| CN-100575341-C | The derivative of tetrahydro-indolone and the derivative of tetrahydro-indazolone and their application | GUOYAO LONGLI BIOLOG MEDICAL NEW TECHNOLOGY CO LTD BEIJING | 2009-12-30 | — | — | CN | claimed |
| CN-101481353-A | Tetrahydro indazolone or tetrahydro indolone substituted indazole derivative and salt thereof | BEIJING GYLONGLY BIOMEDTECH LT (CN) | 2009-07-15 | — | — | CN | claimed |
| CN-1896060-A | Tetrahydro-indolone and tetrahydro-indazolone derivatives and their use | GUOYAO LONGLI BIOLOG MEDICAL N (CN) | 2007-01-17 | — | — | CN | claimed |
| CN-1660184-A | Combination of medicaiton containing extractive of herb of glabrous sarcandra, and preparation method and application | XU GUOLIANG (CN) | 2005-08-31 | — | — | CN | claimed |