Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 4/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31482851 | 1.00 | MAPT (0.43) | MAPTLMNAHTTBLMPIK3CA | |
| SCHEMBL17001600 | 1.00 | MAPT (0.43) | MAPTLMNAHTTBLMPIK3CA | |
| SCHEMBL17018289 | 1.00 | MAPT (0.43) | MAPTLMNAHTTBLMPIK3CA | |
| SCHEMBL31027125 | 0.87 | MAPT (0.43) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL2067967 | 0.87 | MAPT (0.43) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL2067965 | 0.87 | MAPT (0.43) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL15405445 | 0.87 | MAPT (0.43) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL22439195 | 0.83 | APP (0.44) | MAPTLMNAHTTBLMPIK3CA | |
| SCHEMBL22439193 | 0.83 | APP (0.44) | MAPTLMNAHTTBLMPIK3CA | |
| SCHEMBL30601579 | 0.83 | APP (0.44) | MAPTLMNAHTTBLMPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | MAPT 3607/4885LMNA 1766/4885HTT 1733/4885 |
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | MAPT 3607/4885LMNA 1766/4885HTT 1733/4885 |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | MAPT 3607/4885LMNA 1766/4885HTT 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.