Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | RAF1 | P04049 | 5/20 | 0.59 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15575322 | 0.90 | KMT2A (0.62) | LMNARAF1DDR2KMT2AALDH1A1 | |
| SCHEMBL15574664 | 0.88 | RAF1 (0.77) | RAF1DDR2KMT2AKDRBRAF | |
| SCHEMBL13603627 | 0.83 | DDR2 (0.70) | LMNARAF1DDR2KMT2AALDH1A1 | |
| SCHEMBL15573239 | 0.81 | RAF1 (0.52) | RAF1DDR2KMT2AKDRBRAF | |
| SCHEMBL15574685 | 0.81 | KMT2A (0.64) | LMNARAF1DDR2KMT2AALDH1A1 | |
| SCHEMBL13603827 | 0.80 | KDR (0.60) | RAF1DDR2KMT2AKDRBRAF | |
| SCHEMBL17000015 | 0.80 | RAF1 (0.56) | RAF1DDR2KMT2AKDRBRAF | |
| SCHEMBL5429857 | 0.79 | KMT2A (0.54) | LMNARAF1DDR2KMT2AALDH1A1 | |
| SCHEMBL15573188 | 0.78 | RAF1 (0.58) | RAF1DDR2KMT2AKDRBRAF | |
| SCHEMBL15573129 | 0.77 | RAF1 (0.62) | RAF1DDR2KMT2AKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | LMNA 2196/4885RAF1 3072/4885DDR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.