Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004297 | 0.90 | PDE2A (0.46) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004361 | 0.87 | PDE2A (0.55) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004314 | 0.85 | PDE2A (0.54) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004354 | 0.85 | PDE2A (0.48) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004316 | 0.84 | PDE2A (0.50) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL936083 | 0.83 | PDE2A (0.67) | PDE2AMAPK14PDE10AALDH1A1KDM4E | |
| SCHEMBL17004350 | 0.83 | PDE2A (0.67) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004299 | 0.82 | PDE2A (0.52) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004306 | 0.81 | PDE2A (0.73) | PDE2ACYP19A1NQO2MMP2MMP9 | |
| SCHEMBL17004323 | 0.81 | PDE2A (0.73) | PDE2ACYP19A1NQO2MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456440-B1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | claimed |