Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.87 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.87 |
| ▸ | CSF1R | P07333 | 3/20 | 0.87 |
| ▸ | KIT | P10721 | 3/20 | 0.87 |
| ▸ | FLT4 | P35916 | 3/20 | 0.87 |
| ▸ | LCK | P06239 | 2/20 | 0.87 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.87 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.87 |
| ▸ | TEK | Q02763 | 2/20 | 0.87 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4813257 | 0.94 | KDR (0.80) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL17004664 | 0.93 | KDR (1.00) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4812046 | 0.93 | KDR (0.89) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4818134 | 0.89 | KDR (0.70) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4820265 | 0.89 | KDR (0.87) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4815260 | 0.89 | KDR (1.00) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4816632 | 0.87 | KDR (0.68) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4816276 | 0.86 | KDR (0.78) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL17004669 | 0.84 | KDR (0.79) | KDRKCNH2CSF1RKITFLT4 | |
| SCHEMBL4815352 | 0.83 | KDR (0.86) | KDRKCNH2CSF1RKITFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | claimed |