Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 3/20 | 0.58 |
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818123 | 0.90 | KDR (0.47) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4817648 | 0.89 | KDR (0.70) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4815143 | 0.88 | KDR (0.49) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4825754 | 0.88 | KDR (0.65) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4818515 | 0.84 | KDR (0.77) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4815541 | 0.84 | KDR (0.57) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4817078 | 0.77 | KDR (0.50) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4815432 | 0.74 | KDR (0.77) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4815117 | 0.74 | KDR (0.47) | KDRCSF1RKITFLT4LCK | |
| SCHEMBL4815705 | 0.73 | KDR (1.00) | KDRCSF1RKITFLT4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |