Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | FLT4 | P35916 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818096 | 0.90 | KDR (0.79) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4807881 | 0.88 | KDR (0.79) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4818825 | 0.88 | KDR (0.75) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4885029 | 0.86 | KDR (0.77) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4815786 | 0.86 | KDR (0.72) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4815393 | 0.84 | KDR (0.76) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4815247 | 0.84 | KDR (0.77) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4816632 | 0.82 | KDR (0.68) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4813322 | 0.82 | KDR (0.84) | KDRKCNH2CSF1RPDGFRBKIT | |
| SCHEMBL4816452 | 0.79 | KDR (0.80) | KDRKCNH2CSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |