Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.55 |
| ▸ | KIT | P10721 | 6/20 | 0.54 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004672 | 1.00 | KDR (0.55) | KDRKITFLT1CHEK1 | |
| SCHEMBL4816967 | 0.81 | KDR (0.67) | KDRKITFLT1CHEK1 | |
| SCHEMBL4815390 | 0.80 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4815369 | 0.80 | KDR (0.64) | KDRKITFLT1 | |
| SCHEMBL4818609 | 0.79 | KDR (0.56) | KDRKITFLT1CHEK1 | |
| SCHEMBL17004680 | 0.79 | KDR (0.56) | KDRKITFLT1CHEK1 | |
| SCHEMBL4817400 | 0.78 | KDR (0.61) | KDRKITFLT1 | |
| SCHEMBL4813450 | 0.77 | KDR (0.71) | KDRKITFLT1 | |
| SCHEMBL4818410 | 0.76 | KDR (0.89) | KDRKITFLT1 | |
| SCHEMBL4818601 | 0.76 | KDR (0.61) | KDRKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |