Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823809 | 0.90 | KDR (0.72) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL4816995 | 0.71 | KDR (0.81) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL4811861 | 0.71 | KDR (0.71) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL4815942 | 0.69 | KDR (0.78) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL4812279 | 0.69 | KDR (0.71) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL5929568 | 0.68 | KDR (1.00) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL4808611 | 0.66 | KDR (0.73) | KDRKCNH2KITFLT1CHEK1 | |
| SCHEMBL4818410 | 0.66 | KDR (0.89) | KDRKITFLT1 | |
| SCHEMBL4817801 | 0.65 | KDR (0.73) | KDRKITFLT1 | |
| SCHEMBL4814667 | 0.65 | KDR (1.00) | KDRKCNH2KITFLT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |