Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.46 |
| ▸ | KIT | P10721 | 14/20 | 0.43 |
| ▸ | FLT1 | P17948 | 12/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820147 | 0.91 | KDR (0.43) | KDRKITFLT1 | |
| SCHEMBL4816278 | 0.91 | KDR (0.43) | KDRKITFLT1 | |
| SCHEMBL4816418 | 0.86 | KDR (0.43) | KDRKITFLT1 | |
| SCHEMBL4817411 | 0.84 | SMN1; SMN2 (0.40) | KDRKITFLT1 | |
| SCHEMBL4815293 | 0.84 | SMN1; SMN2 (0.40) | KDR | |
| SCHEMBL4817105 | 0.83 | KDR (0.45) | KDRKITFLT1 | |
| SCHEMBL4817239 | 0.81 | SMN1; SMN2 (0.40) | KDR | |
| SCHEMBL17004678 | 0.80 | KDR (0.40) | KDRKITFLT1 | |
| SCHEMBL17004679 | 0.80 | KDR (0.40) | KDRKITFLT1 | |
| SCHEMBL4814668 | 0.80 | KDR (0.42) | KDRKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |