Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991331 | 0.90 | KDR (0.37) | KDRGRM5PDGFRB | |
| SCHEMBL1997076 | 0.83 | APP (0.41) | TGFBR1DYRK1AKDRGRM5SCN5A | |
| SCHEMBL1994411 | 0.77 | KDR (0.36) | KDRGRM5PDGFRB | |
| SCHEMBL1990110 | 0.75 | NPC1 (0.41) | DYRK1AGRM5PDGFRBPDGFRA | |
| SCHEMBL6316118 | 0.73 | GRM5 (0.44) | TGFBR1DYRK1AKDRGRM5SCN5A | |
| SCHEMBL6322242 | 0.73 | GRM5 (0.49) | TGFBR1DYRK1AKDRGRM5PDGFRB | |
| SCHEMBL9902614 | 0.70 | SCN5A (0.40) | TGFBR1MAPK14DYRK1AGRM5SCN5A | |
| SCHEMBL6322323 | 0.70 | DYRK1A (0.40) | TGFBR1MAPK14DYRK1AGRM5SCN5A | |
| SCHEMBL6313999 | 0.70 | GRM5 (0.41) | DYRK1AGRM5KITDDR1 | |
| SCHEMBL6316340 | 0.70 | CA12 (0.41) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513102-B1 | ETHYNYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | claimed |