Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939055 | 0.78 | CHEK1 (0.63) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL3146801 | 0.76 | CDK2 (0.62) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL3128890 | 0.74 | MECP2 (0.53) | KDRKMT2AMEN1MAPK10GFER | |
| Water SCHEMBL28126483 | 0.73 | KMT2A (0.70) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL221242 | 0.73 | KMT2A (0.76) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL29391624 | 0.73 | KMT2A (0.76) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL31754524 | 0.72 | KDM4E (0.48) | KMT2AMEN1CHEK1NPC1RAB9A | |
| SCHEMBL618299 | 0.72 | KMT2A (0.57) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL30206142 | 0.72 | KMT2A (0.57) | KDRKMT2AMEN1MAPK10GFER | |
| SCHEMBL4243882 | 0.71 | KMT2A (0.73) | KDRKMT2AMEN1MAPK10GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105223-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | Respivert Limited (GB) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015121660-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2015-08-20 | — | — | WO | disclosed |