Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.55 |
| ▸ | HCK | P08631 | 16/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008535 | 0.98 | MAPK14 (0.53) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008545 | 0.93 | MAPK14 (0.54) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008536 | 0.93 | MAPK14 (0.54) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008781 | 0.93 | MAPK14 (0.54) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008502 | 0.92 | MAPK14 (0.57) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008548 | 0.91 | MAPK14 (0.46) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL17008555 | 0.91 | MAPK14 (0.52) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008515 | 0.91 | MAPK14 (0.53) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008559 | 0.91 | MAPK14 (0.53) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008571 | 0.91 | MAPK14 (0.54) | MAPK14HCKMAPK12SRCTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105223-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | Respivert Limited (GB) | 2016-12-21 | — | — | EP | claimed |
| WO-2015121660-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2015-08-20 | — | — | WO | claimed |
| EP-3105223-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | Respivert Limited (GB) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015121660-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2015-08-20 | — | — | WO | disclosed |