Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.58 |
| ▸ | HCK | P08631 | 16/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008552 | 0.97 | MAPK14 (0.58) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL20106589 | 0.95 | MAPK14 (0.65) | MAPK14HCKMAPK12SRC | |
| SCHEMBL17008587 | 0.93 | MAPK14 (0.58) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008566 | 0.93 | MAPK14 (0.59) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008582 | 0.92 | MAPK14 (0.60) | MAPK14HCKMAPK12SRC | |
| SCHEMBL22898282 | 0.91 | MAPK14 (0.60) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008533 | 0.91 | MAPK14 (0.68) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17017940 | 0.90 | MAPK14 (0.71) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL20106588 | 0.90 | MAPK14 (0.60) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008936 | 0.90 | MAPK14 (0.58) | MAPK14HCKMAPK12SRCTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105223-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | Respivert Limited (GB) | 2016-12-21 | — | — | EP | claimed |
| WO-2015121660-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2015-08-20 | — | — | WO | claimed |
| EP-3105223-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | Respivert Limited (GB) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015121660-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2015-08-20 | — | — | WO | disclosed |