SCHEMBL17009018

SCHEMBL17009018

COc1cnc(C(F)(F)F)cc1C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LCK P06239 1/20 0.45
FYN P06241 1/20 0.45
SYK P43405 1/20 0.43
KDM4E B2RXH2 4/20 0.42
ALDH1A1 P00352 4/20 0.42
HPGD P15428 3/20 0.42
ASPH Q12797 1/20 0.41
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
KMT2A Q03164 1/20 0.40
P2RX3 P56373 1/20 0.40
P2RX2 Q9UBL9 1/20 0.40
PDE10A Q9Y233 1/20 0.39
HCRTR1 O43613 1/20 0.39
HSD17B10 Q99714 2/20 0.39
USP2 O75604 1/20 0.38
CYP2C19 P33261 1/20 0.38
POLQ O75417 1/20 0.37
PDE4B Q07343 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20855557 0.87 HTT (0.42) LMNAPDE10AHCRTR1POLQPDE4B
SCHEMBL1404736 0.85 LCK (0.46) LCKFYNSYKKDM4EALDH1A1
SCHEMBL12809470 0.83 LCK (0.44) LCKFYNKDM4EALDH1A1HPGD
SCHEMBL20855986 0.82 HCRTR1 (0.39) SYKMEN1LMNAKMT2APDE10A
SCHEMBL25260451 0.81 AKR1C3 (0.46) KDM4EALDH1A1HPGDLMNAKMT2A
SCHEMBL31019085 0.81 AKR1C3 (0.46) KDM4EALDH1A1HPGDLMNAKMT2A
SCHEMBL20638877 0.80 SCN10A (0.45) SYKKDM4EMEN1LMNAKMT2A
SCHEMBL30255074 0.80 SCN10A (0.45) SYKKDM4EMEN1LMNAKMT2A
SCHEMBL24769586 0.80 POLQ (0.50) SYKPOLQ
SCHEMBL30016217 0.80 POLQ (0.50) SYKPOLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115599-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2025-04-10 US disclosed
EP-3107912-B1 DERIVATIVES OF 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2024-07-10 EP disclosed
US-20230087882-A1 2-(Het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides BAYER CROPSCIENCE AG (DE) 2023-03-23 US disclosed
US-11274097-B2 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2022-03-15 US disclosed
US-20190241564-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-08-08 US disclosed
US-10364243-B2 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-07-30 US disclosed
US-20170073342-A1 2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-03-16 US disclosed
EP-3107912-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS Bayer CropScience Aktiengesellschaft (DE) 2016-12-28 EP disclosed
WO-2015121136-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2015-08-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11274097-B2 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents CYP8B1, CYP4B1, CYP1B1 LCK 4562/4885FYN 3178/4885SYK 4457/4885
US-20190241564-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS CYP8B1, CYP4B1, CYP1B1 LCK 4562/4885FYN 3178/4885SYK 4457/4885
US-10364243-B2 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides CYP1B1, CYP4B1, CYP8B1 LCK 3964/4885FYN 1751/4885SYK 4120/4885
US-20230087882-A1 2-(Het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides CYP1B1, CYP4B1, CYP8B1 LCK 3713/4885FYN 1439/4885SYK 3860/4885
US-20170073342-A1 2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES CYP1B1, CYP4B1, CYP8B1 LCK 3964/4885FYN 1751/4885SYK 4120/4885
US-20250115599-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS CYP8B1, CYP4B1, CYP1B1 LCK 4562/4885FYN 3178/4885SYK 4457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.