Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16282507 | 1.00 | PREP (0.55) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL115134 | 0.92 | SMN1; SMN2 (0.52) | PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28616033 | 0.90 | PREP (0.53) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL1875019 | 0.86 | PREP (0.54) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL4344988 | 0.85 | KDM1A (0.54) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL221538 | 0.85 | PREP (0.55) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL221539 | 0.85 | PREP (0.55) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL221540 | 0.85 | PREP (0.55) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL16282508 | 0.84 | PREP (0.48) | PREPACE2NPSR1TSHRL3MBTL1 | |
| SCHEMBL15372095 | 0.84 | PREP (0.59) | PREPACE2NPSR1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123355-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |