Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352306 | 0.79 | DAO (1.00) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL10163846 | 0.77 | DAO (0.69) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL1701349 | 0.77 | DAO (0.69) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| Methane SCHEMBL28127314 | 0.77 | DAO (0.96) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL6196814 | 0.75 | GSK3B (0.44) | DAORAB9AMAPTL3MBTL1GSK3B | |
| SCHEMBL20274867 | 0.74 | DAO (0.65) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL13814173 | 0.74 | DAO (0.65) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL3659417 | 0.74 | DAO (0.65) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL29256521 | 0.71 | DAO (0.61) | DAORAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL25184460 | 0.70 | GSK3B (0.50) | GSK3BLMNAALDH1A1PTPN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585459-B1 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMA SPA (IT) | 2015-01-07 | — | — | EP | disclosed |
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | disclosed |
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | disclosed |
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | disclosed |
| EP-2585459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHRM3, CHRM5, CHRM2 | DAO 178/4885RAB9A 1151/4885SMN1; SMN2 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.