Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 17/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL15117436 | 1.00 | CHRM3 (0.39) | CHRM3CHRM2CHRM1NPSR1LMNA | |
| Trifluoroacetic Acid SCHEMBL2485611 | 0.95 | CHRM3 (0.41) | CHRM3CHRM2CHRM1NPSR1 | |
| Trifluoroacetic Acid SCHEMBL2996006 | 0.95 | CHRM3 (0.41) | CHRM3CHRM2CHRM1NPSR1 | |
| SCHEMBL12072382 | 0.94 | CHRM3 (0.39) | CHRM3CHRM2CHRM1NPSR1LMNA | |
| SCHEMBL12071852 | 0.94 | CHRM3 (0.39) | CHRM3CHRM2CHRM1NPSR1LMNA | |
| SCHEMBL15127407 | 0.94 | CHRM3 (0.39) | CHRM3CHRM2CHRM1NPSR1LMNA | |
| Trifluoroacetic Acid SCHEMBL2998194 | 0.94 | CHRM3 (0.41) | CHRM3CHRM2CHRM1NPSR1 | |
| Trifluoroacetic Acid SCHEMBL16341108 | 0.93 | CHRM3 (0.41) | CHRM3CHRM2CHRM1NPSR1 | |
| Trifluoroacetic Acid SCHEMBL15117690 | 0.92 | CHRM3 (0.40) | CHRM3CHRM2CHRM1 | |
| Trifluoroacetic Acid SCHEMBL2984440 | 0.90 | CHRM3 (0.40) | CHRM3CHRM2CHRM1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | claimed |
| EP-2585459-B1 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMA SPA (IT) | 2015-01-07 | — | — | EP | disclosed |
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | disclosed |
| EP-2585459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHRM3, CHRM5, CHRM2 | CHRM3 1/4885CHRM2 3/4885CHRM1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.